Description
YM 511 is a potent aromatase (CYP19) inhibitor (IC50 = 0.4 and 0.12 nM at rat ovary and human placenta cells, respectively) that weakly inhibits the synthesis of other steroid hormones. YM 511 decreases plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro (IC50 = 0.13 nM)